A primary interest in the lab is to investigate the molecular and chromatin mechanism that regulate glial cell development. NFIA is a key determinant of glial fate in the developing spinal cord. As a post-doc Stacey found that NFIA and Sox10 cross regulate each other’s function and control glial lineage diversification. Further studies demonstrated that distinct long-range enhancers and 3D chromatin conformations regulate NFIA expression in a lineage-specific manner in the developing spinal cord. Currently we are investigating the mechanisms of this lineage specificity and the dynamics of 3D architecture during glial development.
